Wegovy vs Olive Oil – The Truth About GLP-1: Similar or Not?
“I heard olive oil works like Wegovy. Is that true?”
Lately, I’ve been hearing this question a lot.
Maybe you’ve heard it too?
Today, we’re going to dive into the GLP-1 connection between Wegovy (semaglutide) and olive oil — and do it in a fun, easy-to-read way.
I’ll share expert insights, scientific facts, and practical tips along the way.
1. First things first: What is Wegovy?
Wegovy is a GLP-1 receptor agonist medication.
GLP-1 (Glucagon-like peptide-1) is a hormone naturally released in your gut that:
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Boosts insulin secretion → lowers blood sugar
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Slows down stomach emptying → keeps you feeling full longer
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Sends a “Stop eating!” signal to your brain → reduces appetite
Think of GLP-1 as your body’s “diet messenger.”
The problem is, this messenger normally only pops in for a short visit.
Wegovy basically hires this messenger full-time.
So instead of working part-time after meals, it’s on duty all day — and even all week.
2. Where does olive oil come into the picture?
The main fat in olive oil is oleic acid, a monounsaturated fatty acid.
Some research shows oleic acid can stimulate certain gut cells (L-cells) to produce a bit more GLP-1.
On top of that, olive oil contains polyphenols that can improve gut microbiota, creating an environment where GLP-1 production works more smoothly.
Here’s the catch:
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Wegovy: Directly binds to GLP-1 receptors → strong, long-lasting effects
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Olive oil: Gently nudges your gut to make a little more GLP-1 → short-lived and mild
If Wegovy is a high-speed bullet train, olive oil is more like a local bus.
They’re headed in the same direction, but the speed, route, and efficiency are very different.
3. The research 📊
In a 2017 Spanish study, healthy adults were given the same meals, but:
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Group 1: Meals with olive oil
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Group 2: Meals with butter
Results? The olive oil group had 25% higher post-meal GLP-1 levels and reported feeling 18% fuller on average.
The effect lasted about 2–3 hours after eating.
That’s still tiny compared to Wegovy’s effects — 4–7x higher GLP-1 levels lasting up to a week — but in daily life, small differences like this can add up.
4. Expert opinion
When I asked an endocrinology professor at Seoul National University Hospital whether olive oil could replace Wegovy, the answer was clear:
“You can’t directly substitute one for the other. The strength and duration of effects between medication and food aren’t comparable.
However, including olive oil in a Mediterranean-style diet can have positive effects on metabolic health and weight control over time.”
Translation: Olive oil is a supporting actor, not the main star.
5. Fun analogy
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Wegovy: A personal trainer who works you out every single day
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Olive oil: A friend who says, “Hey, let’s take the stairs today”
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GLP-1: The appetite “brake pedal” in your brain
6. How to use olive oil in daily life
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Salad dressing – olive oil + balsamic vinegar
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Morning bread – dip in extra virgin olive oil instead of butter
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Snack swap – cherry tomatoes or roasted veggies drizzled with olive oil
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Korean twist – use olive oil instead of sesame oil when seasoning veggies
💡 Tip: 1–2 tablespoons a day is enough.
One tablespoon has about 120 calories — so don’t overdo it thinking “more is better.”
7. Final takeaway
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Olive oil can mildly boost GLP-1 levels — that’s true
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But it’s nowhere near Wegovy in strength or duration
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As part of a healthy diet, it can still help with weight management and blood sugar control
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“Natural Wegovy” is an exaggeration — better to think of it as “your healthy kitchen sidekick”
💭 Something to think about
The real conversation isn’t just “medicine or food.”
Whether or not you use Wegovy, your dietary fat quality can significantly affect your gut hormone environment — and that’s worth paying attention to.